Is inverse relationship possible between circulating and tissue miRNA?

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Venkateswara Rao Amara on Jun 19, 2016
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I was quantifying miRNA in heart and plasma of rats. I have 4 groups. The groups which showed increased miRNA in heart displayed a corresponding, proportional decrease of the same miRNA in plasma. I searched for any reference showing the justification for this result. I could get only one article "Relationship between Circulating and Tissue microRNAs in a Murine Model", which could not help me.