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Autism spectrum disorders share epigenetic changes observed in the brain

A study led by researchers at the David Geffen School of Medicine at the University of California, Los Angeles (Los Angeles, CA, USA) has demonstrated that individuals with autism spectrum disorder share epigenetic patterns, which could provide potential drug targets.

Go to the profile of Peter Brown
Nov 23, 2016

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Go to the profile of Victor Lobanenkov
Victor Lobanenkov about 1 year ago

Did anyone analyzed if single or dual CTCF sites may correlate genome wide with site/region-specific epigenetic changes and most common DNA deletion or SNPs/indels in ASD patients ?

Go to the profile of Peter Brown
Peter Brown about 1 year ago

Hi Victor, thank you for your comment!

As far as I am aware, within the study they did not analyze any CTCF sites, however they do mention the O'Roak at al., 2011 (Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations) and Sanders et al., 2012 (De novo mutations revealed by whole-exome sequencing are strongly associated with autism) studies in regards to the SLC30A5 zinc transporter gene.

Please do let me know if there's anything else I can help with!